●Chii chinonzi Berberine?
Berberine ndeyechisikigo alkaloid yakabviswa kubva kumidzi, madzinde uye makwati ezvirimwa zvakasiyana, seCoptis chinensis, Phellodendron amurense uye Berberis vulgaris. Ndiyo inonyanya kushanda yeCoptis chinensis ye antibacterial effect.
Berberine ikristaro yeyero yakaita tsono ine kuravira kunovava. Chinhu chikuru chinovava muCoptis chinensis berberine hydrochloride. Iyi isoquinoline alkaloid yakagoverwa mumhando dzakasiyana dzemakwenzi. Inowanikwa muCoptis chinensis muchimiro chehydrochloride (berberine hydrochloride). Zvidzidzo zvakawana kuti komisheni iyi inogona kushandiswa kurapa mapundu, hepatitis, chirwere chemoyo, hypertension, kuzvimba, kutapukira kwebhakitiriya nehutachiona, manyoka, chirwere cheAlzheimer uye arthritis.
● Ndeapi Mabhenefiti Ehutano eBerberine?
1.Antioxidant
Mumamiriro ezvinhu akajairika, muviri wemunhu unochengetedza chiyero pakati pe antioxidants uye prooxidants. Oxidative stress inzira inokuvadza inogona kunge iri murevereri akakosha wekukuvadzwa kwesero, nekudaro zvichikonzera zvirwere zvakasiyana-siyana senge chirwere chemoyo, cancer, chirwere chetsinga uye chirwere cheshuga. Kuwedzeredza kugadzirwa kweiyo reactive oxygen marudzi (ROS), kazhinji kuburikidza nekunyanya kukurudzira kweNADPH nema cytokines kana kuburikidza nemitochondrial electron transport cheni uye xanthine oxidase, zvinogona kutungamirira kune oxidative kusagadzikana. Ongororo dzakaratidza kuti berberine metabolites uye berberine inoratidza zvakanakisisa -OH scavenging basa, iyo inenge yakaenzana neine simba antioxidant vitamin C. Kutungamirirwa kweberberine kumakonzo ane chirwere cheshuga kunogona kutarisa kuwedzera kweSOD (superoxide dismutase) basa uye kuderera kweMDA (a) chiratidzo che lipid peroxidation) mazinga [1]. Mimwe mibairo inoratidza kuti basa rekutsvaira reberberine rakabatana zvakanyanya neiyo ferrous ion chelating chiitiko, uye iyo C-9 hydroxyl boka reberberine chikamu chakakosha.
2.Anti-bundu
Pave paine mishumo yakawanda pamusoro peiyo anti-cancer mhedzisiro yeberberine. Ongororo dzakasiyana mumakore achangopfuura dzakaratidza kuti berberine yakakosha mukurapa adjuvant yezvirwere zvegomarara zvakakomba sekenza yeovarian, kenza yeendometrial, kenza yechibereko, kenza yemazamu, kenza yemapapu, colorectal cancer, itsvo, dundira, uye kenza yeprostate. [2]. Berberine inogona kutadzisa kuwanda kwebundu maseru nekudyidzana neakasiyana zvinangwa uye maitiro. Inogona kushandura kutaura kweoncogenes uye carcinogenesis-inoenderana nemajeni kuti iwane chinangwa chekugadzirisa basa rema enzymes ane hukama kuti adzivise kuwanda.
3.Kuderedza Ropa Lipids Uye Kudzivirira Cardiovascular System
Berberine inoita basa rakakosha mukurapa kwezvirwere zvemoyo uye ine huwandu hwakawanda hwekushandisa. Berberine inozadzisa chinangwa chekurwisa-arrhythmia nekuderedza kuitika kwe ventricular premature beats uye kudzivisa kuitika kwe ventricular tachycardia. Chechipiri, dyslipidemia injodzi huru yechirwere chemoyo, inoratidzwa nehupamhi hwehuwandu hwecholesterol, triglycerides, uye yakaderera-density lipoprotein cholesterol (LDL), uye kuderera kwemazinga e-high-density lipoprotein (HDL), uye berberine inogona kuchengetedza zvakasimba kugadzikana kwezviratidzo izvi. Yenguva refu hyperlipidemia ndicho chikonzero chakakosha chekuumbwa kweatherosclerotic plaque. Zvinonzi berberine inokanganisa LDL receptors muhepatocytes kuderedza vanhu serum cholesterol mazinga muhepatocytes. Kwete izvozvo chete,berberineine inotropic yakanaka uye yakashandiswa kurapa congestive heart failure.
4.Inoderedza Shuga Yeropa Uye Inogadzirisa Endocrine
Diabetes mellitus (DM) chirwere chemetabolism chinoratidzwa nekukwira kwemazinga eshuga muropa (hyperglycemia) kunokonzerwa nekusakwanisa kwepancreatic B masero kuburitsa insulin yakakwana, kana kurasikirwa kweiyo inoshanda inotangwa mhinduro kune insulin. Iyo hypoglycemic effect yeberberine yakawanikwa netsaona muma1980 mukurapa varwere vane chirwere cheshuga vane manyoka.
Zvidzidzo zvakawanda zvakaratidza izvozvoberberineinoderedza shuga yemuropa kuburikidza nenzira dzinotevera:
● Inodzivisa mitochondrial glucose oxidation uye inokurudzira glycolysis, inozowedzera glucose metabolism;
● Inoderedza mazinga eATP nekudzivisa mitochondrial basa muchiropa;
● Inhibits basa reDPP 4 (a ubiquitous serine protease), nokudaro kuparadzanisa mamwe mapeptide anoita kuti awedzere insulini muhupo hwe hyperglycemia.
● Berberine ine simba rinobatsira pakuvandudza insulin kusagadzikana uye kushandiswa kweglucose mumatishu nekuderedza lipids (kunyanya triglycerides) uye plasma isina mafuta acid mazinga.
Summary
Mazuvano,berberineinogona kugadzirwa zvisirizvo uye kugadziridzwa nekristaro engineering nzira. Iine mari shoma uye teknolojia yepamusoro. Nekuvandudzwa kwekutsvagisa kwekurapa uye nekudzika kwemakemikari ekutsvagisa, berberine zvirokwazvo icharatidza mimwe mhedzisiro yemishonga. Kune rimwe divi, berberine haina kungowana mhedzisiro inoshamisa mukutsvagisa kwechinyakare kwemishonga muantibacterial, antiviral, anti-inflammatory, anti-tumor, anti-diabetic, uye kurapwa kwechirwere chemoyo uye cerebrovascular, asiwo dhizaini yayo yekristaro engineering uye morphological analysis. vakawana ngwariro huru. Nekuda kwekuita kwayo kwakakosha uye yakaderera muchetura nemhedzisiro, ine mukana mukuru mukushandiswa kwekiriniki uye ine tarisiro yakakura. Nekuvandudzwa kwesero biology, iyo pharmacological mashandiro eberberine ichajekeswa kubva padanho remaserura uye kunyangwe mamorekuru uye nhanho dzakatarwa, zvichipa hwaro hwekufungidzira hwekushandiswa kwayo kwekiriniki.
● NEWGREEN SupplyBerberine/Liposomal Berberine Powder/Capsules/Tablets
Nguva yekutumira: Oct-28-2024
