Mumakore achangopfuura,NMN, iyo yave nemukurumbira pasi rose, yakabata yakawandisa yekutsvaga inopisa. Zvakawanda sei zvaunoziva nezveNMN? Nhasi, tichatarisa kuunza NMN, iyo inodiwa nemunhu wese.
● ChiiNMN?
NMN inonzi β-Nicotinamide Mononucleotide, kana kuti NMN kwenguva pfupi. NMN ine madiastereomer maviri: α uye β. Zvidzidzo zvakaona kuti chete β-mhando NMN ine biological chiitiko. Zvimiro, iyo morekuru inoumbwa nicotinamide, ribose, uye phosphate.
NMN ndeimwe yevanotangira NAD +. Mune mamwe mazwi, iyo yakakosha mhedzisiro yeNMN inowanikwa kuburikidza nekushandurwa kuita NAD +. Sezvo isu tichikura, mwero weNAD + mumuviri wemunhu unodzikira zvishoma nezvishoma.
Mu2018 Aging Biology Research Compilation, nzira mbiri dzakakosha dzekuchembera kwevanhu dzakapfupikiswa:
1. Kukuvadza kunokonzerwa neoxidative stress (zviratidzo zvinoratidzira sezvirwere zvakasiyana-siyana)
2. Kudzikira kwemazinga eNAD+ mumaseru
Huwandu hukuru hwebudiriro yedzidzo muNAD + yekurwisa kuchembera nevesainzi vepamusoro pasi rose vanotsigira mhedziso yekuti kuwedzera NAD + mazinga anogona kuvandudza hutano mune zvakawanda zvinhu uye kunonoka kuchembera.
● Chii chinonzi Health Benefits ofNMN?
1.Kuwedzera NAD+ zvirimo
NAD + chinhu chakakosha kuchengetedza kushanda kwemuviri. Inowanikwa mumaseru ese uye inotora chikamu muzviuru zvemaitiro emuviri mumuviri. Anopfuura mazana mashanu ma enzymes mumuviri wemunhu anoda NAD +.
Kubva pamufananidzo, tinogona kuona kuti mabhenefiti ekuwedzera NAD + kunhengo dzakasiyana siyana anosanganisira kuvandudza hutano hwehuropi netsinga system, chiropa neitsvo, tsinga dzeropa, moyo, lymphatic tishu, nhengo dzekubereka, pancreas, adipose tishu, uye tsandanyama.
Muna 2013, timu yekutsvagisa inotungamirwa naProfessor David Sinclair weHarvard Medical School yakaratidza kuburikidza nekuyedza kuti mushure mekutonga nemuromo kweNMN kwevhiki imwe, iyo NAD + nhanho mumakonzo ane mwedzi makumi maviri nemaviri yakawedzera, uye akakosha biochemical zviratidzo zvine chekuita nemitochondrial homeostasis uye. basa remhasuru rakadzoserwa kuchimiro chembeva diki dzakaenzana nemwedzi ye6.
2. Shandisa SIR mapuroteni
Tsvagiridzo mumakore makumi maviri apfuura yakawana kuti Sirtuins inoita basa rakakura rekutonga mune angangoita ese maseru mabasa, anokanganisa maitiro emuviri akadai sekuzvimba, kukura kwesero, circadian rhythm, simba metabolism, neuronal basa uye kusagadzikana kusagadzikana.
Sirtuins inowanzonzi iyo hupenyu hurefu hweprotein mhuri, inova mhuri yeNAD + -inotsamira deacetylase mapuroteni.
Muna 2019, Muzvinafundo Kane AE weDhipatimendi reGenetics paHarvard Medical School nevamwe vakazvionaNMNndiyo yakakosha inotungamira kune synthesis yeNAD + mumuviri. Mushure mokunge NMN ichiwedzera chiyero cheNAD + mumasero, akawanda emigumisiro yaro inobatsira (yakadai sekuvandudza metabolism, kuchengetedza mwoyo yemwoyo, nezvimwewo) inowanikwa nekuita Sirtuins.
3. Gadzirisa DNA kukanganisa
kuwedzera pakukanganisa basa reSirtuins, mwero weNAD + mumuviri zvakare yakakosha substrate yeDNA kugadzirisa enzyme PARPs (poly ADP-ribose polymerase).
4. Kurudzira metabolism
Metabolism muunganidzwa wekuita kwemakemikari anochengetedza hupenyu muzvisikwa, zvichivabvumira kukura nekuberekana, kuchengetedza chimiro chavo, uye kupindura kune zvakatipoteredza. Metabolism inzira iyo zvipenyu zvinoramba zvichichinjana zvinhu uye simba. Kana yangomira, hupenyu hwechipenyu huchapera. Muzvinafundo Anthony weYunivhesiti yeCalifornia nechikwata chake vakawana kuti NAD+ metabolism yave mushonga unogona kuvandudza zvirwere zvine chekuita nekuchembera nekuwedzera hutano hwevanhu uye hupenyu.
5. Kurudzira kuvandudzwa kwemidziyo yeropa uye kuchengetedza tsinga yeropa elasticity
Mitsipa yeropa matishu akakosha ekutakura okisijeni nekudya kunovaka muviri, kugadzirisa kabhoni dhaikisaidhi uye metabolites, uye kugadzirisa tembiricha yemuviri. Sezvatinokura, tsinga dzeropa zvishoma nezvishoma dzinorasikirwa nekushanduka kwayo, dzinova dzakaoma, dzakakora, uye dzakatetepa, zvichiita kuti "arteriosclerosis."
Muna 2020, ongororo yakaitwa nevamwe vadzidzi vePhD kubva kuZhejiang University of Technology kuChina, kusanganisira Sh, yakawana kuti mushure mekutonga nemuromoNMNkune mbeva dzakaora mwoyo, zviratidzo zvekuora mwoyo zvakaderedzwa nekuwedzera NAD + mazinga, kumisa Sirtuin 3, uye kuvandudza mitochondrial simba metabolism muhippocampus uye masero echiropa ehuropi hwembeva.
6. Chengetedza hutano hwemwoyo
Mwoyo ndiyo nhengo inonyanya kukosha mumuviri wemunhu uye yakakosha pakuchengetedza kushanda kwemoyo. Kuderera kweNAD + mazinga ane hukama neiyo pathogenesis yezvirwere zvakasiyana zvemoyo. Nhamba huru yezvidzidzo zvekutanga zvakaratidzawo kuti kuwedzera coenzyme ini ndinogona kubatsira mhando dzechirwere chemoyo.
7. Chengetedza hutano hwehuropi
Neurovascular dysfunction inogona kukonzera kutanga kwevascular uye neurodegenerative cognitive kukuvara. Kuchengeta neurovascular basa kwakakosha mukudzivirira zvirwere zveurourodegenerative.
Zvinhu zvine njodzi dzakadai sechirwere cheshuga, hypertension yepakati pehupenyu, kufutisa kwepakati pehupenyu, kusaita zvemuviri uye kuputa zvese zvine chekuita nevascular dementia uye chirwere cheAlzheimer.
8. Kuvandudza insulin senitivity
Insulin senitivity inotsanangura chiyero che insulin kuramba. Iyo yakaderera iyo insulin senitivity, iyo yakaderera dhigirii yekuputsika kweshuga.
Insulin kuramba inoreva kudzikira kwekunzwa kwenhengo dzakatarwa dze insulin pakuita kwe insulin, kureva kuti, mamiriro einojairwa dhizimusi ye insulin inoburitsa yakaderera pane yakajairwa biological maitiro. Chikonzero chikuru chechirwere cheshuga chechipiri ndechekudzikira kwe insulin uye kushomeka kwe insulin senitivity.
NMN, sekuwedzera, inogona kubatsira kuvandudza insulin senitivity nekuwedzera NAD + mazinga, kudzora nzira dzemetabolism, nekuvandudza mitochondrial basa.
9. Kubatsira nekugadzirisa uremu
Kurema hakungokanganisa hupenyu hwehupenyu uye hutano, asiwo hunova chikonzero chezvimwe zvirwere zvisingaperi. Zvidzidzo zvakaratidza kuti NAD precursor β-nicotinamide mononucleotide (NMN) inogona kudzoreredza zvimwe zvakashata zvinokonzerwa nekudya kwemafuta akawanda (HFD).
Muna 2017, Muzvinafundo David Sinclair weHarvard Medical School neboka rekutsvagisa kubva kuAustralian Medical School vakaenzanisa mbeva dzechikadzi dzakafutisa dzaidzidzira patreadmill kwemavhiki e9 kana dzakabaiwa neNMN mazuva ese kwemazuva gumi nemasere. Zvigumisiro zvakaratidza kuti NMN yakaita seine simba rakasimba pachiropa chemafuta metabolism uye synthesis pane kurovedza muviri.
●Kuchengetedzwa kweNMN
NMN inoonekwa seyakachengeteka mukuedza kwemhuka, uye mhedzisiro yacho inokurudzira. Huwandu hwe19 huyedzo hwekiriniki hwevanhu hwakatangwa, iyo 2 yakaburitsa mhinduro dzekuyedza.
Boka rekutsvagisa kubva kuWashington University Chikoro cheMishonga muSt. Louis rakaburitsa chinyorwa mumagazini yepamusoro yesainzi "Sayenzi", ichiburitsa mhedzisiro yenyika yekutanga kuyedza yekiriniki yevanhu, ichisimbisa metabolic zvinobatsira zveNMN pamuviri wemunhu.
●NEWGREEN Supply NMN Powder/Capsules/Liposomal NMN
Nguva yekutumira: Oct-15-2024
