ChiiGlabridin?
Glabridin is flavonoid inotorwa kubva kumidzi ye licorice (Glycyrrhiza glabra) uye ine zvakasiyana-siyana zvehupenyu hwehupenyu uye hutano hunobatsira. glabridin inozivikanwa nekuchena kwayo kwakasimba, antioxidant uye anti-inflammatory properties uye inoshandiswa zvakanyanya mukuchengetedza ganda uye zvizoro.
Glycyrrhiza glabra L. is a perennial herb inokura kumaodzanyemba kweEurope, Asia, uye nharaunda yeMediterranean. Inodyarwa zvakanyanya muRussia, Spain, Iran, neIndia. Chirimwa cheG. glabra chinenge 1-1.5 mamita kureba, nemashizha maduku akasvibira, yero, bhuruu, uye violet maruva, uye rhizome inotapira.
Glabridin ndeimwe yeakanyanya flavonoids muGlycyrrhiza glabra. Inoratidza yakasimba anti-free radical oxidation effect mu cytochrome P450/NADPH oxidation system, uye inogona kuvharidzira zvakanyanya mahara radicals anogadzirwa panguva yemetabolism mukati memuviri kudzivirira oxidation-sensitive biomacromolecules (yakaderera-density lipoprotein LDL, DNA) uye maseru madziro kubva pakukuvadzwa nemahara radical oxidation. Izvi zvinogona kudzivirira uye kubata dzimwe shanduko dzepathological dzine chekuita nemahara radical oxidation, senge atherosclerosis uye kuchembera kwesero. Mukuwedzera, glabridin ine imwe mhedzisiro yekudzikisa lipids yeropa uye BP. Ongororo yeItaly yakasimbisawo kuti Glabridin ine appetite suppressant effect, iyo inogona kuderedza mafuta pasina kuderedza uremu. Mushure mekuedzwa kwakadzokororwa, mhedzisiro huru ndeyotevera: 1. Kuchena, kuvharidzira melanin; 2. Anti-inflammatory effect; 3. Antioxidant effect; 4. Antibacterial.
Zvenyama Uye Zvemakemikari Zvivakwa zveGlabridin
1. Kuumbwa Kwemakemikari
Zita reKemikari: Glabridin
Chemical Formula: C20H20O4
Molecular Weight: 324.37 g/mol
Structural Characteristics: Glabridin isanganiswa yeflavonoid ine yakajairika flavonoid musana chimiro. Iine zvindori zviviri zvinonhuhwirira (A neB) zvakabatanidzwa nezambuko rekabhoni matatu rinoumba mhete yepirani yakavharwa.
2. Zvinhu Zvenyama
Chitarisiko: Glabridin inowanzoita sechena kana yakachenuruka yero crystalline poda.
Solubility:
Mvura: Haina kunyungudika mumvura.
Organic Solvents: Soluble mu organic solvents senge ethanol, methanol, uye propylene glycol.
Melting Point: Inenge 156-158 ° C (313-316 ° F).
Kunhuwa: Glabridin kazhinji haina kunhuhwirira kwakasiyana.
3. Chemical Properties
Kugadzikana: Glabridin inenge yakagadzikana pasi pemamiriro ezvinhu akajairika asi inogona kuderera kana yakaratidzwa kune chiedza, kupisa, kana acidic mamiriro. Inokurudzirwa kuichengeta munzvimbo inotonhorera, yakaoma, kure nechiedza chezuva.
pH Sensitivity: Glabridin inonzwisisa pH shanduko uye inogona kuderera munzvimbo dzine acidic zvakanyanya kana dzakakosha.
Reactivity: Seflavonoid, glabridin inogona kuita maitiro emakemikari anoenderana ne phenolic compounds, zvakadai se oxidation uye conjugation.
Ndezvipi ZvakanakiraGlabridin?
1. Ganda Kuchena uye Kupenya
- Inhibition yeTyrosinase: Glabridin inonyanyozivikanwa nekuchena kwayo ganda. Inodzivirira kuita kwe tyrosinase, enzyme yakakosha pakugadzirwa kwe melanin, nekudaro ichidzikisa kuumbwa kwemavara akasviba uye hyperpigmentation.
- Kunyangwe Ganda Tone: Nekudzikisa melanin synthesis, glabridin inobatsira mukuwana yakawedzera kunyange ganda toni uye kupenya kweganda.
2. Antioxidant Properties
- Yemahara Radical Scavenging: Glabridin ine yakasimba antioxidant zvivakwa, iyo inobatsira mukumisa mahara radicals. Izvi zvinoderedza oxidative kusagadzikana uye kudzivirira kukuvara kweserura.
- Anti-Kuchembera: Iyo antioxidant basa yeglabridin inobatsira mukudzikisa zviratidzo zvekuchembera, senge mitsetse yakanaka, wrinkles, uye zera mavara, nekudzivirira ganda kubva mukukuvadzwa kweiyo oxidative.
3. Anti-Inflammatory Effects
- Kuderedza Kuzvimba: Glabridin inoratidzira anti-inflammatory properties, iyo inobatsira mukuderedza kuputika kweganda, kubwinya, uye kuzvimba.
- Inonyaradza Mhedzisiro: Inogona kunyaradza ganda rakatsamwa uye inobatsira kune mamiriro senge mburwa, eczema, uye rosacea.
4. Antimicrobial Activity
- Inhibition yePathogens: Glabridin yakaratidza antimicrobial properties kurwisana nemabhakitiriya akasiyana-siyana uye fungi. Izvi zvinoita kuti zvive zvakakosha mukudzivirira nekurapa zvirwere zveganda.
- Acne Treatment: Iro antimicrobial uye anti-inflammatory properties inoita kuti glabridin ibudirire mukurapa acne nekuderedza kukura kwebhakitiriya uye kuzvimba.
5. UV Dziviriro
- Photoprotection: Glabridin inogona kupa imwe nhanho yekudzivirira kubva kune UV mwaranzi. Inobatsira mukudzikisa kukuvara kweganda kunokonzerwa neUV, sekupisa kwezuva uye photoaging.
- Synergistic Effect: Kana yakashandiswa pamwe chete nemamwe majenti ezuva, glabridin inogona kuwedzera iyo yakazara photoprotective effect.
6. Kuporeswa Kwemaronda
- Inokurudzira Kuporesa: Glabridin inogona kukurudzira kupora kweronda nekuderedza kuzvimba uye oxidative kusagadzikana, uye nekukurudzira kuvandudzwa kwemasero eganda.
-Kuderedza Scar: Inogonawo kubatsira mukudzikisa kutaridzika kwemavanga nekusimudzira hutano hwekuvandudzwa kweganda.
7. Kuchengeta Bvudzi
- Utano Hwemusoro: Glabridin's anti-inflammatory uye antimicrobial properties inogona kubatsira utano hwemusoro, kuderedza dandruff uye kuputika kwemusoro.
- Bvudzi Kukura: Nekuvandudza hutano hwemusoro, glabridin inogonawo kukurudzira kukura kwebvudzi.
Ndeapi Maapplication EGlabridin?
Cosmetics uye Skincare
1.Skin Whitening Products
- Whitening Creams uye Serums: Glabridin chinhu chakakosha mune dzakawanda ganda kuchena uye kupenya zvigadzirwa nekuda kwekugona kwayo kuvharidzira basa re tyrosinase uye kuderedza kugadzirwa kwe melanin.
- Spot Kurapa: Inoshandiswa mukugadzira ine chinangwa chekudzikisa rima mavara, hyperpigmentation, uye isina kuenzana ganda tone.
2.Anti-Kukwegura Zvigadzirwa
- Anti-Aging Creams uye Lotions: Iyo antioxidant zvimiro zve glabridin zvinobatsira mukudzikisa zviratidzo zvekuchembera, senge mitsetse yakanaka, wrinkles, uye zera mavara.
-Makirimu Eziso: Kazhinji anosanganisirwa mumakirimu eziso kuderedza madenderedzwa akasviba uye kuzvimba.
3.Anti-Inflammatory uye Soothing Products
- Soothing Gels uye Creams: Glabridin's anti-inflammatory properties inoita kuti ive yakakodzera kune zvigadzirwa zvakagadzirirwa kunyaradza ganda rinoputika kana rinopisa.
-Acne Treatments: Inoshandiswa muzvigadzirwa zvekurapa acne kuderedza kuzvimba uye kukura kwebhakitiriya.
4.Sun Kudzivirira Zvigadzirwa
- Sunscreens: Glabridin inogona kuiswa mune sunscreens kuti ipe imwe dziviriro kubva kune UV-induced ganda kukuvara.
-After-Sun Care: Inoshandiswa muzvigadzirwa zvezuva-shure kunyaradza uye kugadzirisa ganda rakapiswa nezuva.
Pharmaceuticals
1. Topical Mishonga
- Anti-Inflammatory Creams: Inoshandiswa mumishonga yepamusoro kurapa ganda rinoputika mamiriro akadai se eczema, psoriasis, uye dermatitis.
-Maronda Anoporesa Mafuta: Inosanganisirwa mumigadziriso ine chinangwa chekusimudzira kuporeswa kwemaronda uye kuderedza kuumbwa kwevanga.
2. Oral Supplements
- Antioxidant Supplements: Glabridin's antioxidant properties inoita kuti ive chinhu chinokosha mumuromo wekuwedzera kune chinangwa chekuderedza oxidative kusagadzikana uye kukurudzira hutano hwose.
-Immune Boosters: Inoshandiswa mune zvekuwedzera zvakagadzirirwa kusimudzira immune basa nekuda kweiyo anti-kuzvimba uye antimicrobial properties.
Kuchengeta Bvudzi
1.Marapirwo emumusoro
- Anti-Dandruff Shampoos: Glabridin's antimicrobial uye anti-inflammatory properties inoita kuti ibudirire mukurapa dandruff uye kuputika kwemusoro.
- Scalp Serums: Inoshandiswa mumaseramu emusoro kusimudzira hutano hwemusoro wemusoro uye inogona kukurudzira kukura kwebvudzi.
2.Hair Conditioners
- Conditioners uye Bvudzi Masks: Inosanganisirwa mune vhudzi kuchengetedza zvigadzirwa kupa antioxidant kudzivirira uye kugadzirisa bvudzi hutano.
Zvokudya Nezvinwiwa
Functional Foods
- Health Drinks: Glabridin inogona kuwedzerwa kune zvinwiwa zvehutano uye zvinwiwa zvinoshanda kuti ipe antioxidant uye anti-inflammatory benefits.
-Nutritional Bars: Inoshandiswa mumabhawa ezvekudya uye masvutugadziro ane chinangwa chekusimudzira hutano hwese uye kugara zvakanaka.
Tsvakurudzo uye Kubudirira
Biomedical Research
-Kutsvagisa Kenza: Glabridin inodzidzwa kune yayo inogona kurwisa kenza zvimiro, kusanganisira kugona kwayo kuvharidzira cancer cell kukura uye kuita apoptosis.
-Kutsvagisa Chirwere Chisingaperi: Yakaferefetwa kune zvayakanakira mukugadzirisa zvirwere zvisingaperi seshuga uye chirwere chemoyo nekuda kweiyo anti-kuzvimba uye antioxidant zvimiro.
Inoenderana Mibvunzo Unogona Kufarira:
Zvinotora nguva yakareba sei kutora licoriceglabridinkurerutsa ganda?
Nguva inotora kuti licorice inotorwa ine glabridin irerutse ganda inogona kusiyana zvichienderana nezvinhu zvakati wandei, kusanganisira kuwanda kwe glabridin muchigadzirwa, kuwanda kwekushandiswa, rudzi rweganda remunhu, uye kuoma kwe hyperpigmentation. Heano mamwe mazano akajeka uye kufunga:
1. Yakajairika Nguva Yenguva
- Yekutanga Mhedzisiro: Vamwe vashandisi vanogona kutanga kuona kuvandudzwa kweganda uye kudzikiswa kwe hyperpigmentation mukati memavhiki maviri kusvika mana ekushandiswa kwakafanana.
- Yakakosha Mhedzisiro: Inooneka uye yakakosha kupenya kweganda mhedzisiro inowanzoitika mushure memavhiki masere kusvika gumi nemaviri ekugara achishandiswa.
2. Zvinhu Zvinokonzera Kubudirira
Kuwedzera kweGlabridin
- Yepamusoro Concentrations: Zvigadzirwa zvine huwandu hwakanyanya hweglabridin (semuenzaniso, 0.5% kusvika 1%) zvinogona kuburitsa nekukurumidza uye zvakanyanya kutaurwa mhedzisiro.
- Yakaderera Concentrations: Zvigadzirwa zvine kudzika kwakadzika zvinogona kutora nguva yakareba kuratidza zvinooneka maitiro.
Kuwanda Kwekushandisa
-Kushandisa Kwezuva Nezuva: Kuisa chigadzirwa kamwe kana kaviri zuva nezuva, sezvakakurudzirwa, kunogona kuwedzera kushanda uye kukurumidzira mhedzisiro.
-Kusapindirana Kushandisa: Kusajaira kushandisa kunogona kunonoka zvinooneka mhedzisiro uye kuderedza kushanda kwese.
Ganda Rudzi uye Mamiriro
-Skin Type: Vanhu vane ganda rakapfava vanogona kuona mhedzisiro nekukurumidza zvichienzaniswa neaya ane dema ganda.
- Kuoma kweHyperpigmentation: Mild hyperpigmentation inogona kupindura nokukurumidza kurapwa, asi dzimwe nyaya dzakaoma dzinogona kutora nguva yakareba kuratidza kuvandudzwa.
3. Complementary Skincare Routine
- Kudzivirirwa kweZuva: Kushandisa sunscreen zuva nezuva kwakakosha kana uchishandisa zvigadzirwa zvinovheneka ganda kudzivirira imwe pigmentation uye kudzivirira ganda kubva kukukuvara kweUV.
- Moisturization: Kuchengeta ganda rakanyorova kunogona kuwedzera kunyura uye kushanda kwezvigadzirwa zvine glabridin.
- Exfoliation: Kugara uchibvisa kunogona kubatsira kubvisa masero eganda akafa uye kukurudzira kupinda kwezvinhu zvinoshanda, zvinogona kukurumidza mhedzisiro.
4. Clinical Studies uye Uchapupu
- Clinical Studies: Zvimwe zvidzidzo zvekliniki zvakaratidza kuti glabridin inogona kuderedza zvakanyanya hyperpigmentation uye kuvandudza ganda mukati me8 kusvika kumavhiki e12 ekushandiswa nguva dzose.
- Zvipupuriro zvemushandisi: Vazhinji vashandisi vanotaura vachiona kuvandudzwa kweganda ravo uye kudzikiswa kwemavara matema mukati memavhiki mashoma kusvika kumwedzi mishoma yekugara kwekushandisa.
Ndeapi maside effects eiyoglabridin?
Glabridin ine zvinhu zvakasiyana-siyana zvehupenyu uye hutano hunobatsira, asi mune dzimwe nguva, kushandisa zvigadzirwa zvine glabridin zvinogona kukonzera mimwe migumisiro. Izvi zvinotevera zvinogona kuitika uye zvidziviriro zve glabridin:
1. Kushatirwa kweganda uye Allergic Reactionns
Skin Irritation
- Zviratidzo: zvinogona kusanganisira kutsvuka, kuzvimba, kukwenya, kuruma, kana kunzwa kupisa.
- Zvinokonzera: Kunzwa kweganda kune glabridin kana zvimwe zvinongedzo muchigadzirwa zvinogona kukonzera kushatirwa kweganda.
Allergic Reactions
- Zviratidzo: zvinogona kusanganisira mapundu, erythema, kuzvimba, kana kukwenya zvakanyanya.
- Zvinokonzera: Allergy kune glabridin kana zvimwe zvinongedzo mune chigadzirwa, izvo zvinogona kukonzeresa allergic reaction.
2. Photosensitivity
- Kuwedzera Sensitivity kuChiedza cheZuva: glabridin inogona kuwedzera kunzwa kweganda kuchiedza chezuva, zvichitungamira mukupisa kwezuva kana photosensitivity dermatitis.
- Kudzivirira: Paunenge uchishandisa zvigadzirwa zvine glabridin, zvinokurudzirwa kushandisa yakakura-spectrum sunscreen uye kudzivirira kuratidzwa kwenguva refu kuzuva.
3. Hormonal Effects
- Inogona Kuitwa Hormonal Activity: Nepo glabridin ichinyanya kuitirwa kushandiswa kwemusoro, zvimwe zvikamu zve licorice (senge glycyrrhizic acid) zvinozivikanwa zvine steroid-semhedzisiro inogona kukanganisa hormone balance.
- Kufunga: Paunenge uchishandisa zvigadzirwa zvine glabridin muhuwandu hwakawanda kwenguva yakareba, unofanirwa kutarisisa kuti uone kana paine zviratidzo zvekusawirirana kwehomoni.
4. Kudyidzana nemamwe Skincare Ingredients
- Kugona Kukurukurirana: glabridin inogona kuwirirana nezvimwe zvinoshandiswa zvinoshandiswa (zvakadai sevhitamini C, retinol, nezvimwewo), zvichikanganisa kushanda kwayo kana kuwedzera njodzi yemigumisiro.
- Kurudziro: Paunenge uchishandisa zvigadzirwa zvine glabridin, zvinokurudzirwa kuti udzivise kushandiswa panguva imwe chete yezvimwe zvakasimba zvinoshanda zvinosanganisa kana kubvunza dermatologist usati washandisa.
5. Systemic Migumisiro
- Kunyura kwakaganhurirwa:glabridininonyanya kushandiswa kushandiswa kwekunze uye ine zvishoma systemic absorption, saka systemic side effects haina kunyanya kuwanda.
- Chengetedzo: Kana iwe uchinge wasangana nekusagadzikana kana kusagadzikana, iwe unofanirwa kurega kuishandisa nekukurumidza uye bvunza chiremba wako.
6. Nhumbu uye Kuyamwisa
- Chengetedzo Chengetedzo: Parizvino pane mashoma data nezve kuchengetedzeka kwe glabridin muvakadzi vane nhumbu uye vanoyamwisa.
- Kurudziro: Vakadzi vane pamuviri uye vanoyamwisa vanofanira kubvunza chiremba wavo vasati vashandisa zvigadzirwa zvine glabridin.
Nguva yekutumira: Sep-21-2024
