ChiiResveratrol?
Resveratrol musanganiswa wechisikigo unowanikwa mune zvimwe zvirimwa, michero, uye waini tsvuku. Ndeyeboka remakomboni anonzi polyphenols, anoita seanooxidants uye anozivikanwa nekugona kwavo kunaka kwehutano. Resveratrol inonyanya kuwanda muganda remazambiringa matsvuku uye yanga iri nyaya yezvidzidzo zvakawanda nekuda kwekugona kwayo kuita pane akasiyana siyana ehutano.
Imwe tsvagiridzo inoratidza kuti resveratrol inogona kuve nemabhenefiti ehutano hwemoyo, sezvo inogona kubatsira kutsigira hutano tsinga uye kutenderera. Pamusoro pezvo, yakadzidzwa kune yayo inogona anti-kuzvimba uye antioxidant zvimiro, izvo zvinogona kuve nemhedzisiro yehutano hwese uye kuchembera maitiro.
Resveratrol yakaferefetwa zvakare nezve basa rayo rinogona kuita mukutsigira hutano hwehuropi uye kugona kwekuziva, pamwe nemhedzisiro yayo pametabolism uye zvingangobatsira zvehuremu.
Zvenyama uye Kemikari Zvivakwa zveResveratrol
Resveratrol (3-4'-5-trihydroxystilbene) isiri-flavonoid polyphenol compound. Zita rayo remakemikari ndiro 3,4',5-trihydroxy-1,2-diphenylethylene (3,4',5-trihydroxystilbene), chimiro chayo chemakemikari ndeyeC14H12O3, uye uremu hwayo hwema molecular ndeye 228.25.
Iyo yakachena resveratrol inoratidzika seyakachena kusvika kune yakapfava yero hupfu, isinganhuhwi, isinganyungudika mumvura, uye inonyungudika nyore nyore muorganic solvents senge ether, chloroform, methanol, ethanol, acetone, uye ethyl acetate. Panonyungudika i253-255°C, uye tembiricha yepasi i261°C. Inogona kutsvuka ine alkaline mhinduro senge ammonia mvura, uye inogona kuita neferric chloride-potassium ferrocyanide. Ichi chivakwa chinogona kushandiswa kuona resveratrol.
Natural resveratrol ine zvimiro zviviri, cis uye trans. Iyo inonyanya kuwanikwa mune trans conformation mune zvakasikwa. Izvo zvimiro zviviri zvinogona kusanganiswa neglucose kugadzira cis uye trans resveratrol glycosides. Cis- uye trans-resveratrol glycosides inogona kusunungura resveratrol pasi pechiito che glycosidase mumatumbo. Pasi pechiedza cheultraviolet, trans-resveratrol inogona kushandurwa kuita cis-isomers.
Kugadzirira Nzira
Natural plant extraction method
Mazambiringa, knotweed uye nzungu anoshandiswa semidziyo yekubvisa uye kupatsanura crude resveratrol, uye woichenesa. Iwo main crude extraction tekinoroji anosanganisira organic solvent extraction, alkaline kubviswa uye enzyme kubviswa. Nzira nyowani dzakaita senge microwave-yakabatsirwa kudhirowa, CO2 supercritical extraction uye ultrasonic-yakabatsirwa kuburitsa inoshandiswa zvakare. Chinangwa chekuchenesa ndechekuparadzanisa cis- uye trans-isomers ye resveratrol uye resveratrol kubva kune crude resveratrol kuti uwane trans-resveratrol. Nzira dzakajairwa dzekuchenesa dzinosanganisira chromatography, silica gel column chromatography, yakaonda layer chromatography, yakakwira performance liquid chromatography, nezvimwe.
Synthesis nzira
Kubva zviri mukati meresveratrolmumiti yakaderera zvikuru uye mari yekuchera yakakwira, kushandiswa kwemakemikari, biological, genetic engineering nedzimwe nzira dzekutora resveratrol yave nzira inokosha mukukura kwayo. Perkin reaction, Hech reaction, uye Witting-Hormer reaction inzira dzakakura dzemakemikari dzekugadzira resveratrol, ine goho re55.2%, 70%, uye 35.7% zvichiteerana. Genetic engineering tekinoroji inoshandiswa kudzora kana kuvandudza biosynthesis nzira ye resveratrol kuti iwane yakakwirira-goho chirimwa strains; nzira dzakadai sekushandisa mutagenesis kusarudza mitsara yepamusoro-yegoho inogona kuwedzera resveratrol goho ne 1.5 ~ 3.0 nguva.
Chii ChinobatsiraResveratrol?
Resveratrol yanga iri nyaya yekutsvagisa nekuda kwekugona kwayo hutano mabhenefiti. Mamwe emabhenefiti angangoita resveratrol anosanganisira:
1.Anti-kuchembera
Muna 2003, purofesa weHarvard University, David Sinclair nechikwata chake vakawana kuti resveratrol inogona kumisa acetylase uye kuwedzera hupenyu hwembiriso, izvo zvakakonzera kuwedzera kwekutsvaga kwekurwisa kuchembera pa resveratrol. Howitz et al. vakawana kuti resveratrol inogona kushanda seyakasimba kwazvo activator yeakanyarara ruzivo regulation 2 homolog1 (SIRT1), inogona kutevedzera anti-kuchembera mhinduro yecalorie restriction (CR), uye kutora chikamu mukutonga kweavhareji yehupenyu hwezvipenyu. . CR inducer yakasimba yeSIRT1 uye inogona kuwedzera kutaura kweSIRT1 munhengo uye matishu akadai sehuropi, moyo, ura, itsvo, tsandanyama uye mafuta. CR inogona kukonzera shanduko yemuviri inononoka kuchembera uye kuwedzera hupenyu, iyo inonyanya kukosha inogona kuwedzerwa ne50%. . Zvidzidzo zvakasimbisa kuti resveratrol inogona kuwedzera hupenyu hwembiriso, nematodes, nhunzi dzemichero uye hove dzakaderera.
2.Anti-bundu, anti-cancer
Resveratrol ine akakosha inhibitory mhedzisiro pane akasiyana bundu maseru akadai sembeva hepatocellular carcinoma, kenza yemazamu, cancer cancer, gastric cancer, uye leukemia. Dzimwe nyanzvi dzakasimbisa kuti resveratrol ine yakakosha inhibitory mhedzisiro pamasero emelanoma kuburikidza neMTT nzira uye kuyerera kwe cytometry.
Pane mishumo yekuti resveratrol inogona kuwedzera cancer radiotherapy uye nekudzikamisa mhedzisiro yekenza stem maseru. Asi kusvika ikozvino, nekuda kwekuoma kwe resveratrol's anti-tumor mechanism, vatsvakurudzi havasati vasvika pakubvumirana pamusoro pekuita kwayo.
3.Kudzivirira uye kubata chirwere chemwoyo
Zvidzidzo zveEpidemiological zvakaona kuti chiitiko che "French paradox" ndechekuti vanhu veFrance vanodya mafuta akawanda zuva rega rega, asi chiitiko uye kufa kwezvirwere zvemoyo zvakanyanya kuderera kupfuura dzimwe nyika dzeEurope. Chiitiko ichi chinogona kunge chine chekuita nekushandisa kwavo kwezuva nezuva kwewaini yakawanda. , uye resveratrol inogona kunge iri iyo huru inoshanda yekudzivirira chinhu. Tsvagiridzo inoratidza kuti resveratrol inogona kudzora mazinga echolesterol eropa nekusunga kune eestrogen receptors mumuviri wemunhu, inhibisa maplatelet kubva pakugadzira magwamba eropa uye kunamatira kumadziro etsinga yeropa, nekudaro ichidzivirira uye kuderedza kuitika uye kukura kwechirwere chemoyo, uye kuderedza njodzi yeropa. chirwere chemoyo mumuviri wemunhu. Ngozi yechirwere chevascular.
4.Antioxidant Tsigiro:Resveratrolinoshanda se antioxidant, inobatsira kuchengetedza masero kubva mukukuvadzwa kweiyo oxidative kunokonzerwa nemahara radicals. Izvi zvinogona kuve nemhedzisiro yehutano hwese uye kuchembera maitiro.
6. Utano Hwouropi: Tsvakurudzo yakatsvaga basa rinogona kuitwa resveratrol mukutsigira hutano hwehuropi uye basa rekuziva, uye zvimwe zvidzidzo zvinoratidza neuroprotective properties.
7.Metabolism uye Weight Management: Resveratrol yakaongororwa nekuda kwezvinogona kuitika pametabolism uye basa rayo mukutsigira hutano hwehutano hwehutano.
Chii chinonzi Applications OfResveratrol?
Resveratrol ine maapplication akasiyana siyana uye inoshandiswa muminda dzakasiyana nekuda kwekugona kwayo hutano mabhenefiti. Zvimwe zvekushandisa resveratrol zvinosanganisira:
1. Zvokudya Zvokudya: Resveratrol inowanzoshandiswa muzvokudya zvinowedzera, kazhinji inotengeswa nokuda kwayo inogona kuva antioxidant uye anti-aging properties.
2. Skincare Zvigadzirwa: Resveratrol inosanganisirwa mune zvimwe zvigadzirwa zve skincare nekuda kweiyo antioxidant zvinhu, izvo zvinogona kubatsira kudzivirira ganda kubva mukukuvadzwa kwezvakatipoteredza uye kutsigira kwese kwehutano hweganda.
3. Functional Foods and Beverages: Resveratrol dzimwe nguva inowedzerwa kune zvokudya zvinoshanda uye zvinwiwa, zvakadai sezvinwiwa zvine simba uye zvigadzirwa zvezvokudya zvinotarisana nehutano, kupa hutano hunobatsira.
4. Tsvakurudzo uye Kubudirira: Resveratrol inoramba iine tsvakurudzo yesayenzi, nezvidzidzo zvinoramba zvichitsvaga zvingangoitika mumamiriro ezvinhu ehutano akasiyana-siyana uye zvinokonzerwa nekukwegura, metabolism, uye hupenyu hwose.
Chii chinonzi Downside yeResveratrol?
Kunyange zvazvo resveratrol yakadzidzwa nekuda kwehutano hwayo hunogona kubatsira, zvakakosha kuti utarise zvinogona kuderera kana zvipimo zvine chekuita nekushandiswa kwayo. Zvimwe zvekufunga nezve kuderera kwe resveratrol zvinosanganisira:
1. Yakaganhurirwa Bioavailability: Resveratrol ine zvishoma zvishoma bioavailability, zvinoreva kuti muviri unogona kusatora uye kuishandisa zvakanaka kana uchitorwa nemuromo. Izvi zvinogona kukanganisa kushanda kwayo mukugadzira hutano hunodiwa.
2. Kushaikwa kweKumira: Hunhu uye kusungirirwa kwezvekuwedzera resveratrol kunogona kusiyana, uye pane kushaikwa kwekumisikidza mukugadzirwa kwezvinowedzera izvi. Izvi zvinogona kuita kuti zviome kune vatengi kuona zvakakodzera dosi uye mhando yechigadzirwa.
3. Kukurukurirana Kunobvira: Resveratrol inogona kuwirirana nemimwe mishonga kana mamiriro ehutano. Zvakakosha kuonana nenyanzvi yezvehutano usati washandisa resveratrol, kunyanya kana uri kutora mimwe mishonga kana kuti une zvinetso zveutano.
4. Zvipingamupinyi zvekutsvakurudza: Kunyange zvazvo zvimwe zvidzidzo zvakaratidza migumisiro inovimbisa, kumwe kutsvakurudza kunodiwa kuti unzwisise zvizere migumisiro yenguva refu, dhigirii yakakwana, uye njodzi dzinogona kuitika dzine chokuita ne resveratrol supplementation.
Sezvinoita chero chekuwedzera, zvinokurudzirwa kuti usvike pakushandiswa kwe resveratrol nekuchenjerera uye uchitungamirwa nenyanzvi yezvehutano, kunyanya kana uine zvinonetsa nezvehutano kana uri kutora mimwe mishonga.
Inoenderana Mibvunzo Yaunogona Kufarira:
Ndiani anofanira kudzivisaresveratrol?
Vamwe vanhu vanofanirwa kungwarira kana kudzivirira resveratrol, kunyanya mune yakawedzera fomu yekuwedzera. Zvinokurudzirwa kuti mapoka anotevera ataurirane nenyanzvi yezvehutano asati ashandisa resveratrol:
1. Vakadzi Vane Mimba kana Vanoyamwisa: Nekuda kwekutsvakurudza kushoma pamusoro pezvinoita resveratrol panguva yekuzvitakura nekuyamwisa, zvinokurudzirwa kuti vakadzi vane pamuviri kana vanoyamwisa vatsvake mazano kubva kune nyanzvi yehutano vasati vashandisa resveratrol supplement.
2. Vanhu Vanotora Ropa Vakaonda: Resveratrol inogona kunge ine anticoagulant zvinyoro zvishoma, saka vanhu vanotora mishonga inoderedza ropa vanofanira kuonana nenyanzvi yehutano vasati vashandisa resveratrol kuti vadzivise kusangana kunogona kuitika.
3. Avo vane Hormone-Sensitive Conditions: Resveratrol yakadzidzwa nekuda kwezvinogona kuitika pakugadzirisa mahomoni, saka vanhu vane hormone-sensitive conditions kana avo vari pasi pehomoni therapy vanofanira kushandisa resveratrol nekuchenjerera uye pasi pekutarisirwa kwechiremba.
4. Vanhu vane Chiropa Mamiriro ezvinhu: Zvimwe zvidzidzo zvakaratidza kuti mazinga makuru e resveratrol anogona kuva nemigumisiro pachiropa. Vanhu vane zvirwere zvechiropa kana avo vanotora mishonga inobata chiropa vanofanira kushandisa resveratrol nekuchenjerera uye pasi pekutarisirwa kwechiremba.
Sezvinoita chero chekuwedzera, zvakakosha kubvunzana nenyanzvi yezvehutano usati washandisa resveratrol, kunyanya kana uine chainetsekana nezvehutano, uri kutora mishonga, kana uine mamiriro ehutano.
Chii chinoita resveratrol paganda?
Resveratrol inofungidzirwa kuti inopa akati wandei mabhenefiti eganda, izvo zvakakonzera kuti ibatanidzwe muzvigadzirwa zvekuchengetedza ganda. Mimwe yemhedzisiro ye resveratrol paganda inogona kusanganisira:
1. Antioxidant Kudzivirirwa: Resveratrol inoshanda se antioxidant, inobatsira kuderedza mahara radicals uye kuderedza oxidative kusagadzikana muganda. Izvi zvinogona kudzivirira ganda kubva mukukuvadzwa kwezvakatipoteredza, senge UV mwaranzi uye kusvibiswa.
2. Anti-Aging Properties: Resveratrol inofungidzirwa kuti ine anti-aging effects, sezvo inogona kubatsira kuderedza kutaridzika kwemitsara yakanaka uye wrinkles, kunatsiridza kusununguka kweganda, uye kutsigira hutano hweganda rose.
3. Anti-Inflammatory Effects: Resveratrol yakadzidzwa nekuda kweiyo inogona kurwisa-kupisa zvinhu, izvo zvinogona kubatsira kunyaradza uye kudzikamisa ganda, kunyanya kune vanhu vane ganda rinonzwa kana reactive.
4. Kupenya Kweganda: Imwe tsvakurudzo inoratidza kuti resveratrol inogona kuita kuti ganda rive rakajeka uye manheru kunze kweganda, zvichiita kuderedza kuonekwa kwe hyperpigmentation.
Ndechipi chikafu chakanyanya mu resveratrol?
Chikafu chakanyanya mu resveratrol zvinosanganisira:
1. Red Grapes: Resveratrol inonyanya kuwanda muganda remazambiringa matsvuku, zvichiita kuti waini tsvuku ive sosi ye resveratrol. Nekudaro, zvakakosha kunwa doro zvine mwero, uye zvimwe zvitubu zve resveratrol zvinogona kusarudzwa kune vasiri kunwa.
2. Nzungu: Dzimwe mhando dzenzungu, kunyanya ganda renzungu, dzine huwandu hunozivikanwa hwe resveratrol.
3. Blueberries: Blueberries inozivikanwa nokuda kwehutano hwe antioxidant, uye inewo resveratrol, kunyange mune zviduku zvishoma kana zvichienzaniswa nemazambiringa matsvuku uye nzungu.
4. Cranberries: Cranberries ndiyo imwe nzvimbo ye resveratrol, inopa huwandu hune mwero hwemusanganiswa uyu.
5. Chokoreti Yakasviba: Mamwe marudzi echokoreti yakasviba ane resveratrol, inopa nzira inonaka yekubatanidza iyi komputa mukudya.
Zvakanaka here kutora resveratrol mazuva ese?
Sarudzo yekutora resveratrol zuva rega rega inofanirwa kuitwa mukubvunzana nenyanzvi yezvehutano, kunyanya kana uchifunga nezve resveratrol yekuwedzera. Kunyange zvazvo resveratrol inowanzoonekwa seyakachengeteka kana ichidyiwa muhuwandu hunowanzo kuwanikwa muzvokudya, kuchengeteka uye zvingangobatsira zvezuva nezuva resveratrol supplementation zvinogona kusiyana zvichienderana nehutano hwemunhu, mamiriro ehutano aripo, uye mimwe mishonga iri kutorwa.
Resveratrol ine chepfu pachiropa here?
Resveratrol yakadzidzwa nekuda kwezvinogona kuitika pachiropa, uye nepo ichiwanzoonekwa seyakachengeteka kana ichidyiwa muhuwandu hunowanzo kuwanikwa muchikafu, pane humwe humbowo hunoratidza kuti madhasi akakwira eresveratrol anogona kuve nemhedzisiro pachiropa. Zvimwe zvidzidzo zvakaratidza kuti madhasi akakwira e resveratrol anogona kutungamira kune chiropa chepfu mune mamwe mamiriro.
Zvakakosha kuziva kuti tsvakiridzo yenyaya iyi irikuenderera mberi, uye mukana wehupfu hwechiropa unogona kukanganiswa nezvinhu zvakaita sedosi, nguva yekushandiswa, uye hutano hwemunhu. Sezvinoita chero chekuwedzera, zvinokurudzirwa kubvunzana nenyanzvi yezvehutano usati washandisa resveratrol, kunyanya kana uine hutano chaihwo kana uri kutora mimwe mishonga inogona kukanganisa kushanda kwechiropa.
Resveratrol yakaipa kuitsvo here?
Pane humbowo hushoma hunoratidza kuti resveratrol yakaipa kune itsvo. Nekudaro, sekunge chero chekuwedzera, zvakakosha kuti uswedere kushandiswa kwayo nekuchenjerera, kunyanya kana uine mamiriro eitsvo aripo kana uri kutora mishonga inogona kukanganisa kushanda kweitsvo. Zvinokurudzirwa kubvunza nyanzvi yezvehutano kuti uone kana resveratrol supplementation yakakodzera pane zvaunoda pahutano hwako wega, kunyanya kana iwe uine zvinokunetsa pamusoro pezvazvinoita pahutano hweitsvo.
Chii chisingasanganisike nachoresveratrol?
Paunenge uchifunga nezve resveratrol yekuwedzera, zvakakosha kuti uzive zvekugona kusangana nezvimwe zvinhu. Zvimwe zvekufunga nezve izvo zvisinga sanganise ne resveratrol zvinosanganisira:
1. Ropa-Kuonda Mishonga: Resveratrol inogona kunge ine anticoagulant zvishoma, saka zvakakosha kushandisa kuchenjerera paunotora resveratrol pamwe chete nemishonga inoderedza ropa, sezvo inogona kuwedzera njodzi yekubuda ropa.
2. Zvimwe Antioxidant Supplements: Nepo ma antioxidants achiwanzo batsira, kutora madosi akakwirira eakawanda ekuwedzera antioxidant panguva imwe chete anogona kuve nemhedzisiro isingatarisirwe. Zvinokurudzirwa kuonana nenyanzvi yezvehutano usati wasanganisa resveratrol nemamwe ma antioxidant supplement.
3. Mimwe Mishonga: Resveratrol inogona kuwirirana nemishonga chaiyo, kusanganisira iyo yakagadziriswa nechiropa. Zvakakosha kukurukura zvinogona kuitika nenyanzvi yezvehutano, kunyanya kana uri kutora mimwe mishonga.
Sezvinoita chero chekuwedzera, zvakakosha kutsvaga nhungamiro kubva kune nyanzvi yezvehutano kuti uone mashandisirwo akakodzera eresveratrol zvichienderana nemamiriro ehutano hwemunhu uye kusangana kunogona kuitika nezvimwe zvinhu.
Ndinogona kushandisa vhitamini C ne resveratrol?
Hongu, iwe unogona kazhinji kushandisa vhitamini C ine resveratrol. Muchokwadi, kumwe kutsvagurudza kunoratidza kuti kusanganisa resveratrol nevhitamini C kunogona kuwedzera iyo antioxidant mhedzisiro yemakomponi ese ari maviri. Vitamin C inozivikanwa kwazvo antioxidant iyo inogona kuzadzisa zvingangobatsira zve resveratrol. Nekudaro, sekunge chero musanganiswa wezvekuwedzera, zvinokurudzirwa kubvunza nyanzvi yezvehutano kuti uve nechokwadi chekuti musanganiswa wacho wakakodzera pane zvaunoda pahutano hwako wega uye kukurukura chero zvingangoitika kana kufunga.
Nguva yekutumira: Sep-09-2024
