Mukusimudzira kwepasi, masayendisiti akafumura kugona kwematrine, musanganiswa wechisikigo unobva pamudzi wechirimwa Sophora flavescens, mukurwisa cancer. Kuwanikwa uku kunoratidza kusimukira kwakakosha mumunda we oncology uye kune mukana wekushandura kurapwa kwegomarara.
Chii chiriMatrine?
Matrine yagara ichishandiswa mumishonga yechinyakare yechiChinese kune yayo inorwisa-kuzvimba uye inorwisa kenza. Nekudaro, nzira dzayo dzekuita dzakaramba dzisinganzwisisike kusvika zvino. Vatsvagiri vachangobva kuita ongororo dzakadzama kuti vaburitse nzira dzemamorekuru kuburikidza iyo matrine inoshandisa maitiro ayo ekurwisa cancer.
Kuburikidza nekuferefeta kwavo, masayendisiti akawana kuti matrine ine simba rinopesana neproliferative uye pro-apoptotic zvimiro, zvichireva kuti inogona kutadzisa kukura kwemaseru egomarara uye kuita kuti sero ravo rife. Ichi chiito cheviri chinoita kuti matrine ave mumiriri anovimbisa mukuvandudzwa kweanoveli cancer ekurapa.
Uyezve, zvidzidzo zvakaratidza izvozvomatrineinogona kutadzisa kufamba uye kupinda kwemasero egomarara, ayo ari maitiro akakosha mukupararira kwegomarara. Izvi zvinoratidza kuti matrine inogona kusashanda chete mukurapa mapundu ekutanga asiwo mukudzivirira metastasis, dambudziko guru mukutarisira cancer.
Pamusoro pemhedzisiro yayo yakananga pamaseru egomarara, matrine yakawanikwa ichigadzirisa tumor microenvironment, ichidzvinyirira kuumbwa kwetsinga dzeropa nyowani dzakakosha pakukura kwebundu. Iyi anti-angiogenic pfuma inowedzera kuwedzera kugona kwe matrine seyakakwana yekurwisa cancer.
Kuwanikwa kwesimba rekudzivirira gomarara rematrine kwaunza mufaro munharaunda yesainzi, nevaongorori vava kutarisisa kuenderera mberi nekuongorora mashandisirwo ayo ekurapa. Miedzo yemakiriniki iri kuenderera mberi yekuongorora kuchengetedzeka uye kushanda kwematrine-based marapirwo muvarwere vegomarara, zvichipa tariro yekuvandudzwa kwemishonga mitsva uye yakavandudzwa yegomarara.
Mukupedzisa, chizaruro chematrine'sAnti-cancer properties inomiririra chiitiko chakakosha muhondo inoenderera mberi yekurwisa cancer. Nemaitiro ayo ane mativi mazhinji echiito uye anovimbisa mhedzisiro yepreclinical, matrine ine vimbiso huru sechombo chenguva yemberi mukurwisa chirwere chinoparadza ichi. Sezvo tsvakiridzo munharaunda iyi iri kuramba ichiitika, kugona kwematrine mukushandura kurapwa kwegomarara hakugone kuwedzeredzwa.
Nguva yekutumira: Sep-02-2024
