Bacopa monnieri, inozivikanwawo sebrahmi muchiSanskrit uye brain tonic muChirungu, inowanzoshandiswa mishonga yeAyurvedic. Ongororo nyowani yesainzi inotaura kuti Indian Ayurvedic herb Bacopa monnieri yakaratidzwa kubatsira kudzivirira chirwere cheAlzheimer (AD). Ongororo iyi, yakabudiswa mupepanhau reScience Drug Target Insights, yakaitwa nechikwata chevaongorori vekuMalaysia kubva kuTaylor University kuUnited States uye vakaongorora hutano hwemabacosides, chikamu chebioactive chechirimwa.
Vachitaura zvidzidzo zviviri zvakaitwa muna 2011, vatsvakurudzi vakataura kuti bacosides inogona kudzivirira huropi kubva mukukuvadzwa kweoxidative uye kuderera kwekuziva kwezera kuburikidza nenzira dzakawanda. Senge isiri-polar glycoside, mabacosides anogona kuyambuka ropa-brain barriers kuburikidza nekureruka lipid-mediated passive diffusion. Zvichienderana nezvidzidzo zvakapfuura, vaongorori vakati ma bacosides anogona zvakare kuvandudza basa rekuziva nekuda kwemahara radical scavenging zvimiro.
Mamwe mabhenefiti ehutano ebacosideszvinosanganisira kudzivirira neurons kubva kuAβ-induced toxicity, peptide inobata basa rinokosha pathogenesis yeAD nokuti inogona kuungana mu insoluble amyloid fibrils. Ongororo iyi inoratidza mashandisirwo anobudirira eBacopa monnieri mukuziva uye neuroprotective application, uye ma phytoconstituents ayo anogona kushandiswa kugadzira mishonga mitsva.Zvirimwa zvakawanda zvechinyakare zvine misanganiswa yakaoma yekomboni ine zvakasiyana siyana zvemishonga uye zvipenyu, kunyanya Bacopa monnieri, iyo inoshandiswa. semishonga yechivanhu uye mukugadzirwa kwezvinhu zvinorwisa kuchembera.
● Zvitanhatu ZvakanakiraBacopa Monnieri
1.Inosimudzira Memory uye Cognition
Bacopa ine akawanda anokwezva mabhenefiti, asi pamwe inonyanya kuzivikanwa nekugona kwayo kuvandudza ndangariro uye cognition. Iyo yekutanga michina iyoBakopakunowedzera ndangariro uye cognition iri kuburikidza nekunatsiridza synaptic kutaurirana. Kunyanya, iyo herb inosimudzira kukura uye kupararira kwe dendrites, iyo inosimudzira nerve chiratidzo.
Cherechedza: Dendrites ibazi-senge nerve cell extensions inogamuchira zviratidzo zvinouya, saka kusimbisa idzi "waya" dzekutaurirana kwehutano hwemagetsi pakupedzisira kunosimudzira basa rekuziva.
Zvidzidzo zvakawana kuti Bacoside-A inomutsa masero etsinga, ichiita kuti ma synapses agamuchire kune anouya nerve impulses. Bacopa yakaratidzawo kuwedzera chiyeuchidzo uye cognition nekukurudzira hippocampal chiitiko nekuwedzera protein kinase chiitiko mumuviri, iyo inogadzirisa nzira dzakasiyana dzemaserura.
Sezvo hippocampus yakakosha kune zvingangoita zvese zviitiko zvekuziva, vaongorori vanotenda iyi ndiyo imwe yenzira dzekutanga iyo Bacopa inowedzera simba rehuropi.
Zvimwe zvidzidzo zvakaratidza kuti zuva nezuva kuwedzera neBacopa monnieri(pamwero we300-640 mg pazuva) inogona kuvandudza:
Kushanda ndangariro
Spatial memory
Unconscious memory
Attention
Kudzidza mwero
Memory consolidation
Kunonoka kurangarira basa
Shoko rendangariro
Visual memory
2.Inoderedza Kushungurudzika uye Kuzvidya Mwoyo
Ingave yezvemari, yemagariro, yemuviri, yepfungwa, kana yemanzwiro, kushushikana inyaya huru muhupenyu hwevanhu vazhinji. Iye zvino kupfuura nakare kose, vanhu vari kutarisira kutiza nenzira ipi neipi inodiwa, kusanganisira zvinodhaka nedoro. Zvisinei, zvinhu zvakadai sezvinodhaka nedoro zvinogona kuva nemigumisiro yakaipa pautano hwepfungwa uye hwomuviri hwomunhu.
Unogona kufarira kuziva izvozvoBakopaine nhoroondo yakareba yekushandiswa sehutano hwemagetsi tonic kuti ibvise manzwiro ekuzvidya mwoyo, kunetseka, uye kushungurudzika.Izvi zvinokonzerwa neBacopa's adaptogenic properties, iyo inowedzera kukwanisa kwemuviri wedu kutsungirira, kushamwaridzana, uye kupora kubva mukushungurudzika (pfungwa, muviri. , uye mupfungwa). Bacopa inoshandisa aya anochinja maitiro muchikamu nekuda kwekutonga kwayo kwevaneurotransmitters, asi iyi miriwo yekare inokanganisawo cortisol mazinga.
Sezvaungave uchiziva, cortisol ndiyo yekutanga kushushikana kwehomoni yemuviri. Kushungurudzika kusingagumi uye mazinga e-cortisol akakwirira anogona kukuvadza uropi hwako.Kutaura zvazviri, nyanzvi dzezveuropiyo dzakaona kuti kusagadzikana kusingaperi kunogona kukonzera kuchinja kwenguva refu mukugadzirwa kwehuropi nekushanda, zvichiita kuti kuwedzeredza kwemamwe mapuroteni anokuvadza neuroni.
Kusagadzikana kusingaperi kunotungamirirawo kukuvadzwa kweoxidative kune neuroni, iyo inogona kuva nemigumisiro yakasiyana-siyana yakaipa, kusanganisira:
Kurasikirwa kwendangariro
Neuron cell kufa
Kukanganisa kuita sarudzo
Atrophy of brain mass.
Bacopa monnieri ine simba rekurevesa kushushikana, neuroprotective zvivakwa. Zvidzidzo zvevanhu zvakanyora iyo adaptogenic mhedzisiro yeBacopa monnieri, kusanganisira kuderedza cortisol. Lower cortisol inotungamirira kukudzikiswa kwekunzwa kwekunetseka, izvo zvisingagoni kungovandudza mafungiro, asiwo kuwedzera kutarisa uye kubudirira. Uyezve, nekuti Bacopa monnieri inodzora dopamine uye serotonin, inogona kudzikisira shanduko-inokonzeresa shanduko mu dopamine uye serotonin muhippocampus uye prefrontal cortex, ichiwedzera kusimbisa iyo adaptogenic hunhu hwemuriwo uyu.
Bacopa monnieriinowedzerawo kugadzirwa kwe tryptophan hydroxylase (TPH2), enzyme inokosha kune zvakasiyana-siyana zvepakati tsinga dzemagetsi, kusanganisira serotonin synthesis. Kunyanya kukosha, bacoside-A, chimwe chezvinonyanya kushanda zvinoshandiswa muBacopa monnieri, yakaratidzwa kuwedzera basa reGABA. GABA inodzikamisa, inhibitory neurotransmitter. Bacopa monnieri inogona kusimudzira basa reGABA uye kuderedza glutamate basa, izvo zvinogona kubatsira kuderedza manzwiro ekuzvidya mwoyo kuburikidza nekuderedza kushandiswa kweeuroni dzinogona kunge dzakanyanyisa. -zvakanaka" vibe.
Nguva yekutumira: Oct-08-2024
