• ChiiTetrahydrocurcumin ?
Rhizoma Curcumae Longae ndiyo yakaoma rhizoma yeCurcumae Longae L. Inoshandiswa zvakanyanya sekudya kwemavara uye kunhuhwirira. Kuumbwa kwayo kwemakemikari kunonyanya kusanganisira curcumin uye mafuta anopisa, kunze kwemasaccharides uye sterols. Curcumin (CUR), seyakasikwa polyphenol mumuti we curcuma, yakaratidzwa kuva nemhando dzakasiyana-siyana dzemishonga, kusanganisira anti-inflammatory, antioxidant, oxygen free radical elimination, kudzivirira chiropa, anti-fibrosis, anti-tumor basa nekudzivirira. yechirwere cheAlzheimer (AD).
Curcumin inokurumidza kushandiswa mumuviri kuita glucuronic acid conjugates, sulfuric acid conjugates, dihydrocurcumin, tetrahydrocurcumin, uye hexahydrocurcumin, iyo inoshandurwa kuita tetrahydrocurcumin. Ongororo dzekuyedza dzakasimbisa kuti curcumin ine kusagadzikana kwakashata (ona photodecomposition), kusagadzikana kwemvura uye kuderera kwebioavailability. Naizvozvo, chikamu chayo chikuru chemetabolism tetrahydrocurcumin mumuviri chave nzvimbo yekutsvagisa kumba nekune dzimwe nyika mumakore achangopfuura.
Tetrahydrocurcumin(THC), seyakanyanya kushanda uye yakakura metabolite ye curcumin inogadzirwa panguva yayo metabolism mu vivo, inogona kuparadzaniswa kubva ku cytoplasm yemukati mudumbu uye chiropa mushure mekutonga kwe curcumin kumunhu kana mbeva. Iyo molecular formula ndeye C21H26O6, iyo molecular uremu i372.2, density i1.222, uye nzvimbo yekunyungudika i95 ℃ -97 ℃.
• Ndezvipi ZvakanakiraTetrahydrocurcuminMukuchengetwa Kweganda?
1. Mhedzisiro pakugadzirwa kwe melanin
Tetrahydrocurcumin inogona kuderedza melanin yemukati muB16F10 masero. Kana iyo inowirirana yekuisa tetrahydrocurcumin (25, 50, 100, 200μmol/L) yakapihwa, melanin yemukati yakaderera kubva pa100% kusvika 74.34%, 80.14%, 34.37%, 21.40%, zvichiteerana.
Tetrahydrocurcumin inogona kurambidza tyrosinase basa muB16F10 masero. Apo kuenzanisa kunowirirana kwe tetrahydrocurcumin (100 uye 200μmol / L) kwakapiwa kumasero, intracellular tyrosinase basa yakaderera kusvika 84.51% uye 83.38%, maererano.
2. Anti-photoaging
Ndapota onai mufananidzo wembeva pazasi: Ctrl (control), UV (UVA + UVB), THC (UVA + UVB + THC THC100 mg/kg, yakanyungudika mu 0.5% sodium carboxymethyl cellulose). Mifananidzo yeganda kuseri kweKM mbeva pamavhiki gumi mushure mekusarudzwa THC kurapwa uye UVA irradiation. Mapoka akasiyana ane yakaenzana UVA flux radiation kusvika pakuchembera akaongororwa neBissett mamaki. Mitemo inoratidzwa ndiyo inorevesa chiyero chekutsauka (N = 12/ boka). *P<0.05, **P
Kubva pakuonekwa, kana ichienzaniswa neboka rinowanzodzora, ganda reboka rekutonga remuenzaniso rakanga rakaomarara, rinooneka erythema, maronda, makwinya akadzika uye akakora, achiperekedzwa neshanduko dzakaita sematehwe, zvichiratidza chiitiko chemifananidzo. Kuenzaniswa neboka rekudzora modhi, dhigirii rekukuvadza retetrahydrocurcumin100 mg / kg boka raive rakaderera zvakanyanya kupfuura iro reboka rekutonga modhi, uye hapana goko uye erythema zvakawanikwa paganda, kungoita pigmentation shoma uye makwinya akanaka akaonekwa.
3. The antioxidant
Tetrahydrocurcumin inogona kuwedzera SOD level, kuderedza LDH level uye kuwedzera GSH-PX level muHaCaT masero.
Kubvisa DPPH yemahara radicals
Thetetrahydrocurcuminmhinduro yakaderedzwa ne10, 50, 80, 100, 200, 400, 800, 1600 nguva dzakateerana, uye mhinduro yemuenzaniso yakanyatsosanganiswa ne0.1mmol/L DPPH mhinduro pachiyero che1:5. Mushure mekuita pane tembiricha yekamuri ye30min, kukosha kwekutora kwakatemwa pa517nm. Chigumisiro chinoratidzwa mumufananidzo:
4. Kudzivisa kuzvimba kweganda
Chidzidzo chekuyedza chakaratidza kuti kuporeswa kwemaronda kwembeva kwakaramba kuchionekwa kwemazuva gumi nemana, pakashandiswa THC-SLNS gel zvichiteerana, kukurumidza kuporesa ronda uye mhedzisiro yeTHC uye kutonga kwakanaka kwaive nekukurumidza uye zvirinani, kudzika kurongeka kwaive THC-SLNS gel. >
THC > Kudzora kwakanaka.
Pazasi pane mifananidzo inomiririra yeakacheneswa ronda mbeva modhi uye histopathological kucherechedza, A1 uye A6 inoratidza zvakajairika ganda, A2 uye A7 inoratidza THC SLN gel, A3 uye A8 inoratidza zvakanaka kudzora, A4 uye A9 kuratidza THC gel, uye A5 uye A10 kuratidza blank yakasimba. lipid nanoparticles (SLN), zvichiteerana.
• Kushandiswa kweTetrahydrocurcuminIn Cosmetics
1.Skin care products:
Anti-Kuchembera Zvigadzirwa:Inoshandiswa mune anti-kuchembera makirimu uye serum kubatsira kuderedza kuunyana uye mitsetse yakanaka uye kunatsiridza elasticity yeganda.
Whitening products:Yakawedzerwa kuchena essences uye makirimu kuti abatsire kunatsiridza kusaenzana kweganda toni uye mavara.
2.Anti-kuzvimba zvigadzirwa:
Inoshandiswa muzvigadzirwa zvekuchengetedza ganda senge zvinozorodza uye kugadzirisa makirimu kuderedza kutsvuka uye kutsamwa.
3.Kuchenesa Zvigadzirwa:
Wedzera kune kuchenesa uye exfoliants kubatsira kuchenesa ganda uye kupa antibacterial mabhenefiti kudzivirira mburwa.
4.Sunscreen Zvigadzirwa:
Inoshanda se antioxidant kusimudzira kushanda kwezuva uye kudzivirira ganda kubva kune UV mwaranzi.
5.Face Mask:
Inoshandiswa mumasikisi akasiyana-siyana echiso kuti ape zvakadzika kudya uye kugadzirisa, kugadzirisa ganda.
Tetrahydrocurcumininoshandiswa zvakanyanya muzvizoro, kuvhara kuchengetedza kweganda, kuchenesa, kudzivirira kwezuva nemimwe minda. Inofarirwa neiyo antioxidant, anti-inflammatory uye whitening mhedzisiro.
Nguva yekutumira: Oct-10-2024
